In each hemi-segment of Drosophila larvae, there are three c4da neurons, ddaC, vada and vdaB, from dorsal to ventral. These findings suggest that regulated proteolytic alteration of the extracellular matrix microenvironment might be a fundamental mechanism to drive a large-scale change of dendritic structures during reorganization of neuronal circuits.Ĭopyright 2010 Elsevier Inc. Loss of JNK leads to dendrite-pruning defects of c4da neurons. Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons. Dendrites display diverse and often complex arborization patterns that are integral to neuron function, as they determine the type of sensory or synaptic input. in Drosophila sensory neurons suppresses PS exposure of injured dendrites. Further genetic analysis indicates that Mmp2 promotes the dendrite reshaping through local degradation of the basement membrane upon which dendrites of the sensory neurons innervate. NAD + reduction is thought to underlie both types of degeneration by inducing. We also find that the dendrite reshaping is completely blocked in mutants for the matrix metalloproteinase (Mmp) 2. This radial-to-lattice reshaping arises from rearrangement of the existing radial branches into the lattice-like pattern, rather than extensive dendrite pruning followed by regrowth of the lattice-shaped arbors over the period. Nevertheless, these examples show that the model is versatile and has predictive potential beyond just Drosophila class IV sensory neurons. Here we show that dendritic arbors of adult Drosophila sensory neurons are rapidly reshaped from a radial shape to a lattice-like shape within 24 hr after eclosion. Different types of neurons, however, often have overlapping dendritic fields. Dendrites allow neurons to integrate sensory or synaptic inputs, and the spatial disposition and local density of branches within the dendritic arbor limit the number and type of inputs1,2. In response to changes in the environment, dendrites from certain neurons change their shape, yet the mechanism remains largely unknown.
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